Article last updated: October 15, 2024
Tetrapeptide-5, also known as N-Acetyl-Tetrapeptide-5, is a synthetic peptide that consists of a sequence of four amino acids: alanine, histidine, and serine. These amino acids are linked together in a specific order to form a peptide chain, which is designed to mimic the natural peptides found in the skin. In the world of cosmetics, Tetrapeptide-5 is primarily recognized for its skin conditioning properties, making it a popular ingredient in various skincare products.
The journey of Tetrapeptide-5 into the realm of cosmetics is relatively recent, driven by advancements in peptide synthesis and a growing understanding of how peptides can benefit the skin. Initially, peptides were explored for their potential in medical applications, but their ability to interact with skin cells and promote various skin benefits soon caught the attention of the cosmetic industry. Tetrapeptide-5, in particular, has been studied for its potential to improve skin texture and hydration, which has led to its inclusion in a range of skincare formulations.
The production of Tetrapeptide-5 involves a process known as solid-phase peptide synthesis (SPPS). This method allows for the precise assembly of amino acids into the desired peptide sequence. During SPPS, the amino acids are sequentially added to a growing peptide chain that is anchored to a solid resin. Protective groups are used to prevent unwanted reactions, ensuring that the amino acids link together in the correct order. Once the peptide chain is complete, it is cleaved from the resin and purified to obtain the final product, which is then ready for use in cosmetic formulations.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Tetrapeptide-5:
Tetrapeptide-5 is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition. In practical terms, this can translate to improved skin texture, enhanced smoothness, and a more even skin tone. By conditioning the skin, Tetrapeptide-5 can make it feel softer and more supple, which is a desirable effect in many skincare products.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Tetrapeptide-5 is generally considered safe for topical application in cosmetic products. It is suitable for most skin types and has a low allergenic potential. However, as with any cosmetic ingredient, there are potential side effects to be aware of:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Tetrapeptide-5 during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to Tetrapeptide-5 are uncommon, but it is always recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, Tetrapeptide-5 has a rating of 0, meaning it is non-comedogenic. This indicates that it is unlikely to clog pores or cause acne, making it suitable for individuals prone to blemishes and breakouts.
