Article last updated: October 15, 2024
Sh-Polypeptide-111 is a fascinating ingredient in the world of cosmetics, known for its skin conditioning and skin protecting properties. This single chain recombinant human peptide is produced through a fermentation process in Escherichia coli (E. coli). The starting gene for this peptide is a synthesized copy of the human gene responsible for coding Disintegrin and Metalloproteinase Domain-containing Protein 15. This gene is either used as-is or adapted to suit the production host. The resulting protein can contain up to 863 amino acids, which may include disulfide bonds and glycosylation, ensuring it consists of the proper sequence of the 20 standard amino acids.
The journey of Sh-Polypeptide-111 into cosmetic products is rooted in the advancements of biotechnology and genetic engineering. Initially, the focus was on understanding and replicating human proteins for medical and therapeutic purposes. Over time, the potential benefits of these proteins for skin health and rejuvenation became apparent, leading to their incorporation into skincare formulations. The use of recombinant DNA technology allows for the precise production of this peptide, ensuring consistency and efficacy in cosmetic applications.
The production process of Sh-Polypeptide-111 involves the insertion of the synthesized human gene into E. coli bacteria. These bacteria then act as tiny factories, producing the peptide through fermentation. Once the fermentation process is complete, the peptide is extracted and purified to ensure it meets the stringent standards required for cosmetic use. This method not only ensures a high level of purity but also allows for scalable production, making Sh-Polypeptide-111 a viable ingredient for various skincare products.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Sh-Polypeptide-111:
Sh-Polypeptide-111 is known for its skin conditioning properties. This means it helps to maintain the skin in good condition by improving its overall appearance and feel. When applied in cosmetic formulations, it can make your skin feel softer, smoother, and more hydrated. Essentially, it acts like a nourishing agent that keeps your skin looking and feeling its best.
Another key benefit of Sh-Polypeptide-111 is its ability to protect the skin. This function involves forming a barrier on the skin’s surface to shield it from environmental aggressors like pollution, UV rays, and harsh weather conditions. By doing so, it helps to prevent damage and maintain the skin’s natural integrity. Think of it as a protective shield that keeps your skin safe from external harm.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Sh-Polypeptide-111 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Sh-Polypeptide-111 during pregnancy and breastfeeding are lacking. Therefore, it is advisable to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from Sh-Polypeptide-111 are relatively uncommon. However, it is recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, Sh-Polypeptide-111 has a rating of 0, meaning it is considered non-comedogenic. This is beneficial for individuals who are prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
