Article last updated: October 15, 2024
Rh-Polypeptide-82, also known as recombinant human polypeptide-82, is a single-chain peptide derived from human genes. This ingredient is produced through a fermentation process involving E. coli bacteria. The gene used to create Rh-Polypeptide-82 is isolated directly from human cells and codes for Angiogenin, a protein known for its role in promoting blood vessel formation. The peptide itself can contain up to 147 amino acids, which may include disulfide bonds and glycosylation, ensuring it has the proper sequence of the 20 standard amino acids.
The journey of Rh-Polypeptide-82 into the world of cosmetics is rooted in biotechnology advancements. Initially, peptides like Angiogenin were studied for their medical applications, particularly in wound healing and tissue regeneration. Over time, researchers discovered that these peptides could also offer significant benefits for skin health, leading to their incorporation into cosmetic formulations. The ability of Rh-Polypeptide-82 to condition and protect the skin made it a valuable addition to skincare products.
The production of Rh-Polypeptide-82 involves a sophisticated biotechnological process. It starts with the extraction of the relevant gene from human cells, which is then inserted into E. coli bacteria. These bacteria act as tiny factories, producing the peptide through fermentation. Once the fermentation process is complete, the peptide is purified and prepared for use in cosmetic products. This method ensures a high level of purity and consistency, making Rh-Polypeptide-82 a reliable ingredient for skincare formulations.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Rh-Polypeptide-82:
Rh-Polypeptide-82 is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition. When applied in cosmetic formulations, it can enhance the appearance and feel of the skin, making it softer, smoother, and more supple. Essentially, it helps to keep your skin looking and feeling its best by providing the necessary nutrients and support to maintain its health and vitality.
Another significant benefit of Rh-Polypeptide-82 is its skin protecting function. This ingredient helps to shield the skin from external aggressors such as environmental pollutants, harsh weather conditions, and other factors that can cause damage. By forming a protective barrier, it aids in preventing moisture loss and keeps the skin hydrated. This protective action helps to maintain the skin’s integrity and resilience, ensuring it remains healthy and less prone to irritation and damage.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Rh-Polypeptide-82 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Rh-Polypeptide-82 during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from Rh-Polypeptide-82 are generally uncommon. However, it is recommended to perform a patch test before widespread usage to ensure there is no adverse reaction.
Rh-Polypeptide-82 has a comedogenic rating of 1, meaning it is very unlikely to clog pores. This makes it suitable for individuals prone to acne, blemishes, or breakouts.
