Article last updated: October 15, 2024
Rh-Polypeptide-33, also known as recombinant human polypeptide-33, is a fascinating ingredient in the world of cosmetics. This single-chain peptide is produced through a fermentation process involving E. coli bacteria. The starting gene for Rh-Polypeptide-33 is directly isolated from a human cell, specifically coding for Tumor Necrosis Factor Alpha (TNF-α). This gene is either used as-is or adapted to suit the production host. The resulting protein can contain up to 233 amino acids, which may include disulfide bonds and glycosylation, ensuring it maintains the proper sequence of the 20 standard amino acids.
The journey of Rh-Polypeptide-33 into cosmetic products is rooted in biotechnology advancements. Initially, peptides like this were explored for their potential in medical and therapeutic applications, particularly in the context of inflammation and immune responses due to their origin from TNF-α. Over time, researchers discovered that these peptides could also offer significant benefits for skin health, leading to their incorporation into skincare formulations.
The production of Rh-Polypeptide-33 involves a sophisticated biotechnological process. It starts with the isolation of the relevant gene from human cells. This gene is then inserted into E. coli bacteria, which act as tiny bio-factories. Through fermentation, these bacteria produce the peptide, which is subsequently purified and refined for use in cosmetic products. This method ensures a high degree of purity and consistency, making Rh-Polypeptide-33 a reliable ingredient for skin conditioning and protection.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Rh-Polypeptide-33:
Rh-Polypeptide-33 is known for its skin conditioning properties. This means it helps to maintain the skin in good condition. When applied, it can improve the appearance and feel of the skin, making it softer, smoother, and more supple. Essentially, it helps your skin look and feel healthier by enhancing its overall texture and resilience.
Another significant benefit of Rh-Polypeptide-33 is its ability to protect the skin. This function involves creating a barrier on the skin’s surface that helps to shield it from environmental stressors such as pollution, UV rays, and harsh weather conditions. By providing this protective layer, Rh-Polypeptide-33 helps to prevent damage and maintain the skin’s integrity, keeping it looking youthful and vibrant.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Rh-Polypeptide-33 during pregnancy and breastfeeding are currently lacking. It is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
While Rh-Polypeptide-33 is generally considered safe for topical application, there are potential side effects that users should be aware of:
These side effects are relatively uncommon, but it is recommended to perform a patch test before widespread usage to ensure individual tolerance.
In terms of comedogenicity, Rh-Polypeptide-33 is rated as a 1 on a scale of 0 to 5, where 0 is totally non-comedogenic and 5 is highly comedogenic. This low rating means it is unlikely to clog pores and is generally suitable for people prone to acne, blemishes, or breakouts.
