Article last updated: October 15, 2024
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47, also known as NBHP-40 Sh-Polypeptide-47, is a sophisticated fusion peptide used in the cosmetic industry primarily for its skin conditioning properties. This ingredient is derived from the Nicotiana benthamiana plant, a relative of the tobacco plant, which has been genetically transformed to produce this unique peptide. The transformation can occur through a transient expression system or through stable transgenesis, where a copy of a human gene is inserted into the plant’s DNA.
The peptide itself is a fusion of Hexapeptide-40 with a single chain recombinant human peptide. The starting gene for this process is synthesized to be identical to the human gene responsible for coding Collagen Alpha-1, which consists of up to 1669 amino acids. The resulting fusion peptide, however, is much shorter, containing 116 amino acids. This peptide may also include disulfide bonds and glycosylation, which are modifications that can influence its stability and function.
The journey of NBHP-40 Sh-Polypeptide-47 into the world of cosmetics is rooted in the quest for advanced skincare solutions. Researchers have been exploring plant-based biotechnologies to produce human-like peptides that can offer similar benefits to those naturally found in our skin. By harnessing the capabilities of Nicotiana benthamiana, scientists have been able to create a peptide that mimics the properties of human collagen, a key protein in maintaining skin elasticity and firmness.
The production process of NBHP-40 Sh-Polypeptide-47 involves the careful insertion of a human gene into the Nicotiana benthamiana plant. Once the plant is transformed, it begins to produce the desired peptide, which is then extracted and purified for use in cosmetic formulations. This innovative approach not only ensures a sustainable source of the peptide but also allows for precise control over its composition and quality.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47:
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 is primarily known for its skin conditioning properties. This means that it helps to maintain the skin in good condition. In practical terms, this ingredient can help to keep your skin feeling soft, smooth, and hydrated. It works by enhancing the skin’s natural barrier, which can help to lock in moisture and protect against environmental stressors. This is particularly beneficial for those with dry or sensitive skin, as it can provide a soothing and nourishing effect.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from this ingredient are generally uncommon. However, it is always a good practice to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47 has a rating of 1 on a scale of 0 to 5, where 0 is totally non-comedogenic and 5 is highly comedogenic. This low rating indicates that it is unlikely to clog pores, making it suitable for individuals prone to acne, blemishes, or breakouts.
