Article last updated: October 15, 2024
Tetrapeptide-34, also known as Gly-Leu-Phe-Trp, is a synthetic peptide composed of four amino acids: glycine, leucine, phenylalanine, and tryptophan. This ingredient is primarily used in the cosmetic industry for its skin conditioning properties, as officially recognized by the CosIng Database.
The journey of Tetrapeptide-34 into the world of cosmetics is relatively recent, driven by advancements in peptide synthesis and a growing interest in bioactive compounds that can enhance skin health. Initially, peptides like Tetrapeptide-34 were studied for their roles in cellular communication and regeneration. As research progressed, scientists discovered that these peptides could be engineered to target specific skin concerns, leading to their incorporation into skincare formulations.
Tetrapeptide-34 is produced through a process known as solid-phase peptide synthesis (SPPS). This method involves sequentially adding amino acids to a growing peptide chain anchored to a solid resin. Each amino acid is protected by a temporary chemical group to prevent unwanted reactions. Once the desired sequence is complete, the peptide is cleaved from the resin and purified. This meticulous process ensures the creation of a highly specific and effective peptide suitable for cosmetic applications.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Tetrapeptide-34:
Tetrapeptide-34 is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition by improving its overall appearance and feel. When used in cosmetic formulations, Tetrapeptide-34 can enhance the skin’s texture, making it feel smoother and more supple. It can also help to maintain the skin’s hydration levels, ensuring it stays moisturized and healthy-looking. Essentially, this ingredient works to keep your skin in its best possible state, providing a foundation for a radiant and youthful complexion.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Tetrapeptide-34 is generally considered safe for topical use in cosmetic products. However, as with any ingredient, there are potential side effects that users should be aware of:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Tetrapeptide-34 during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to Tetrapeptide-34 are relatively uncommon, but it is always prudent to perform a patch test before widespread usage to ensure that your skin does not react negatively to the ingredient.
In terms of comedogenicity, Tetrapeptide-34 has a rating of 0, meaning it is considered non-comedogenic. This is particularly beneficial for individuals who are prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
