Article last updated: October 15, 2024
Sr-Spider Polypeptide-4 is a fascinating cosmetic ingredient derived from an unexpected source: spider silk. Specifically, it is a single chain recombinant spider protein produced through fermentation in E. coli bacteria. The starting gene for this process is a synthesized copy of the gene from the European garden spider, Araneus diadematus, which codes for Dragline Silk Protein Spidroin 1. This protein can contain up to 617 amino acids, potentially featuring disulfide bonds and glycosylation, and consists of the proper sequence of the 20 standard amino acids.
The journey of Sr-Spider Polypeptide-4 into the world of cosmetics is quite intriguing. Initially, spider silk proteins were studied for their incredible strength and elasticity, which sparked interest in various fields, including materials science and medicine. Over time, researchers discovered that these proteins also had potential benefits for skin care, such as enhancing skin conditioning. This led to the development of Sr-Spider Polypeptide-4 as a cosmetic ingredient, leveraging the unique properties of spider silk to improve skin health and appearance.
The production of Sr-Spider Polypeptide-4 involves a sophisticated biotechnological process. Scientists first synthesize the gene that codes for the spider silk protein and then insert this gene into E. coli bacteria. These genetically modified bacteria are cultured in fermentation tanks, where they produce the spider silk protein. After fermentation, the protein is extracted and purified to be used in cosmetic formulations. This method ensures a sustainable and scalable production of the ingredient, making it accessible for use in various skin care products.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Sr-Spider Polypeptide-4:
Sr-Spider Polypeptide-4 is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition, making it feel softer, smoother, and more supple. When applied in cosmetic formulations, this ingredient can enhance the overall texture and appearance of the skin, providing a more youthful and healthy look. It works by forming a protective barrier on the skin’s surface, which helps to retain moisture and prevent dryness. This can be particularly beneficial for individuals with dry or sensitive skin, as it aids in keeping the skin hydrated and comfortable.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Sr-Spider Polypeptide-4 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Sr-Spider Polypeptide-4 during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from Sr-Spider Polypeptide-4 are generally uncommon. However, it is always recommended to perform a patch test before widespread usage to ensure that the ingredient does not cause any adverse reactions on your skin.
In terms of comedogenicity, Sr-Spider Polypeptide-4 is rated as 1 on a scale of 0 to 5, where 0 is totally non-comedogenic and 5 is highly comedogenic. This low rating indicates that it is unlikely to clog pores and is generally suitable for individuals prone to acne, blemishes, or breakouts.
