Article last updated: October 15, 2024
Sh-Tripeptide-2 is a synthetic peptide that has been designed to mimic a specific segment of the Tumor Necrosis Factor Receptor (TNFR). This peptide is composed of three amino acids: histidine and leucine.
The journey of Sh-Tripeptide-2 into the realm of cosmetics is rooted in the broader exploration of peptides for their skin-conditioning properties. Peptides, in general, have been studied for their ability to signal skin cells to perform specific functions, such as collagen production or inflammation reduction. Sh-Tripeptide-2, in particular, was developed to leverage these signaling capabilities, aiming to improve skin texture and resilience.
The creation of Sh-Tripeptide-2 involves sophisticated synthetic processes. Scientists use solid-phase peptide synthesis (SPPS) to assemble the peptide chain. This method allows for precise control over the sequence of amino acids, ensuring that the resulting peptide is identical to the desired segment of the TNFR protein. The synthetic nature of Sh-Tripeptide-2 ensures consistency and purity, making it a reliable ingredient for cosmetic formulations.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Sh-Tripeptide-2:
Sh-Tripeptide-2 is primarily recognized for its skin conditioning properties. This means it helps to maintain the skin in good condition, making it feel softer, smoother, and more supple. When included in skincare products, Sh-Tripeptide-2 can enhance the overall texture and appearance of the skin, providing a more youthful and healthy look. It works by supporting the skin’s natural functions, helping to keep it hydrated and resilient against environmental stressors.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Sh-Tripeptide-2 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Sh-Tripeptide-2 during pregnancy or breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice.
Adverse reactions to Sh-Tripeptide-2 are relatively uncommon, but they can occur. To minimize the risk of irritation or allergic reactions, it is recommended to conduct a patch test before widespread usage.
Sh-Tripeptide-2 has a comedogenicity rating of 0, meaning it is considered non-comedogenic. This makes it suitable for individuals who are prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
