Article last updated: October 15, 2024
Sh-Polypeptide-113 is a single chain recombinant human peptide that has found its way into the world of cosmetics, primarily for its skin conditioning and skin protecting properties. This ingredient is also known by its more scientific name, Lactotransferrin, which is a protein naturally found in human secretions like milk, saliva, and tears. The peptide is produced through a fermentation process in E. coli bacteria, where a synthesized copy of the human gene responsible for Lactotransferrin is introduced into the production host. This results in a protein that can contain up to 710 amino acids, complete with potential disulfide bonds and glycosylation, ensuring it mimics the natural human protein closely.
The journey of Sh-Polypeptide-113 into cosmetic products is rooted in its biological functions and benefits. Initially studied for its antimicrobial and anti-inflammatory properties, Lactotransferrin has been recognized for its ability to support skin health. Over time, researchers and cosmetic formulators saw the potential of this peptide in skincare, leading to its inclusion in various beauty products aimed at enhancing skin condition and protection.
The production of Sh-Polypeptide-113 is a fascinating blend of biotechnology and chemistry. It starts with the synthesis of a human gene copy, which is then inserted into E. coli bacteria. These bacteria act as tiny factories, fermenting and producing the peptide in large quantities. After fermentation, the peptide is extracted, purified, and prepared for use in cosmetic formulations. This method ensures a high level of purity and consistency, making Sh-Polypeptide-113 a reliable ingredient in skincare products.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Sh-Polypeptide-113:
Sh-Polypeptide-113 is known for its skin conditioning properties. This means it helps to maintain the skin in good condition. When applied in cosmetic formulations, it can improve the overall appearance and feel of the skin, making it softer, smoother, and more supple. Essentially, it helps to keep your skin looking and feeling its best by providing essential proteins that support skin health.
Another key benefit of Sh-Polypeptide-113 is its ability to protect the skin. This ingredient can help to shield the skin from environmental stressors and potential damage. By forming a protective barrier, it helps to prevent the skin from losing moisture and guards against harmful external factors like pollution and UV radiation. This protective function is crucial for maintaining healthy, resilient skin.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Sh-Polypeptide-113 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Sh-Polypeptide-113 during pregnancy are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from Sh-Polypeptide-113 are relatively uncommon. However, it is always recommended to conduct a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, Sh-Polypeptide-113 has a rating of 0, meaning it is considered non-comedogenic. This makes it suitable for individuals who are prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
